A Breakthrough in Treating Depression: Understanding Spravato Therapy
- Susan Allen
- Jan 24
- 3 min read
You don’t have to face depression alone. Hope and healing are within reach.
For those living with treatment-resistant depression, finding an effective solution can feel like an uphill battle. Traditional therapies and medications don’t always yield the desired relief, leaving many to wonder if there’s hope for brighter days ahead. That’s where Spravato (esketamine) steps in—a game-changing treatment offering new possibilities for those struggling with severe depression.
What is Spravato?
Spravato is an innovative FDA-approved therapy designed to help adults with treatment-resistant depression. Unlike traditional antidepressants that primarily target serotonin, Spravato works differently by targeting NMDA receptors in the brain. This unique mechanism helps to promote rapid symptom relief and improved mood for many patients who haven’t found success with other treatments.
Administered as a nasal spray in a clinical setting, Spravato is paired with an oral antidepressant to enhance its effectiveness. This combination can address the root causes of depression in a way that offers hope for long-term improvement.
Who is it For?
Spravato is specifically intended for individuals diagnosed with treatment-resistant depression. You may be a candidate for this therapy if:
You’ve tried two or more antidepressants without significant improvement.
You experience severe depressive symptoms that interfere with daily life.
Your mental health care provider believes traditional treatments aren’t providing sufficient relief.
A thorough evaluation with your mental health provider can help determine if Spravato is the right fit for you.
How Does Spravato Therapy Work?
Spravato treatment sessions take place in a controlled, supervised clinical environment. The process typically follows these steps:
Preparation: Before your session, your care team will guide you through what to expect, ensuring you feel comfortable and informed.
Administration: Spravato is self-administered via a nasal spray under medical supervision. The process is quick and painless.
Observation: After administration, you’ll remain in the clinic for two hours. During this time, your care team will monitor your response and ensure your safety.
Follow-Up: Most treatment plans include sessions twice a week for the first month, gradually reducing frequency as your symptoms improve.
Benefits of Spravato:
Spravato’s rapid onset is one of its most remarkable benefits. While traditional antidepressants can take weeks to show results, many patients report noticeable improvements within hours or days of their first dose. Other advantages include:
Enhanced ability to manage depressive symptoms.
Reduced feelings of hopelessness.
Improved overall quality of life.
What to Expect:
Like any medical treatment, Spravato comes with potential side effects. Common experiences include dizziness, nausea, and mild dissociation during or shortly after treatment. Your care team will monitor you closely to ensure your comfort and address any concerns.
Why Choose PsychWellNow for Spravato therapy?
At PsychWellNow, we believe that accessible and innovative care is the key to overcoming mental health challenges. Our team is trained to provide Spravato therapy in a compassionate, supportive environment, ensuring you feel empowered every step of the way.
We also partner with major insurance providers to minimize costs, making this groundbreaking treatment more affordable for our patients.
Ready to Learn More?
If you’ve been battling treatment-resistant depression and are ready to explore new possibilities, Spravato might be the solution you’ve been searching for. Contact PsychWellNow today to schedule a consultation and take the first step toward reclaiming your life!
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The U.S. Food and Drug Administration (FDA) has approved Spravato (esketamine) nasal spray for the treatment of treatment-resistant depression. Initially approved in 2019 for use in conjunction with an oral antidepressant, Spravato received expanded approval in January 2025 as a standalone therapy.
For detailed information on the FDA's approval of Spravato, you can refer to the official press releases:
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